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Mechanistic insights into reprogramming to induced pluripotency

13 Oct 2010

Abstract excerpt

Induced pluripotent stem (iPS) cells can be generated from various embryonic and adult cell types upon expression of a set of few transcription factors, most commonly consisting of Oct4, Sox2, cMyc, and Klf4, following a strategy originally published by Takahashi and Yamanaka (Takahashi and Yamanaka, 2006, Cell 126: 663-676). Since iPS cells are molecularly and functionally similar to embryonic stem (ES) cells,...

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PMID: 20945378
DOI: 10.1002/jcp.22450

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