Article
Mechanisms for enhancing cellular reprogramming.
Current opinion in genetics & development - 1 Apr 2014
Soufi Abdenour
Abstract excerpt
During development, the genome adopts specific chromatin states to establish and maintain functionally distinct cell types in a well-controlled environment. A select group of transcription factors have the ability to drive the transition of the genome from a pluripotent to a more specialized chromatin state. The same set of factors can be used as reprogramming factors to reset the already established chromatin...
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