Article

Frequent and Transient Acquisition of Pluripotency During Somatic Cell Trans-Differentiation with iPSC Reprogramming Factors

2014-08-23

Abstract excerpt

Recent reports have proposed a new paradigm for obtaining mature somatic cell types from fibroblasts without going through a pluripotent state, by briefly expressing canonical iPSC reprogramming factors Oct4 , Sox2 , Klf4 , c-Myc (abbreviated as OSKM) in cells expanded in lineage differentiation promoting conditions. Here we apply genetic lineage tracing for endogenous Nanog locus and X chromosome reactivation...

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Literature Corpus work: be461b4f-0d2d-5d5f-97f4-d4efe317d1f6
DOI: 10.1101/008284

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