Article

Transient Reprogramming of Neonatal Cardiomyocytes to a Proliferative Dedifferentiated State

2019-10-10

Abstract excerpt

Zebrafish and urodele amphibians are capable of extraordinary myocardial regeneration thanks to the ability of their cardiomyocytes to undergo transient dedifferentiation and proliferation. Somatic cells can be temporarily reprogrammed to a proliferative, dedifferentiated state through transient expression of Oct3/4, Sox2, Klf4 and c-Myc (OSKM) transcription factors. Here, we utilized an OSKM-encoding non-integr...

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Literature Corpus work: 58ee65b2-2ce2-53a7-871f-7dfdf0d00865
DOI: 10.1101/801092

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