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Article

Spermatogonial stem cells and progenitors are refractory to reprogramming to pluripotency by the transcription factors Oct3/4, c-Myc, Sox2 and Klf4.

Oncotarget - 7 Feb 2017

Corbineau Sébastien, Lassalle Bruno, Givelet Maelle, Souissi-Sarahoui Inès, Firlej Virginie, Romeo Paul Henri, Allemand Isabelle, Riou Lydia, Fouchet Pierre

Abstract excerpt

The male germinal lineage, which is defined as unipotent, produces sperm through spermatogenesis. However, embryonic primordial germ cells and postnatal spermatogonial stem cells (SSCs) can change their fate and convert to pluripotency in culture when they are not controlled by the testicular microenvironment. The mechanisms underlying these reprogramming processes are poorly understood. Testicular germ cell...

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Identifiers

PMID: 28052023
DOI: 10.18632/oncotarget.14327
PMCID: PMC5354640

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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