Article

In vivo reprogramming and epigenetic rejuvenation of adult cardiomyocytes ameliorate heart failure in mice

2021-12-23

Abstract excerpt

<h4>ABSTRACT</h4> Partial cell reprogramming has been demonstrated in certain mouse tissues by in situ overexpression of Oct3/4 , Klf4 , Sox2 and cMyc (OKSM) transcription factors, and can induce rejuvenation and/or augment regeneration. Reprogramming of adult cardiomyocytes has been elusive until recently, but its success could help overcome the lack of endogenous regenerative capacity of the mammalian myoca...

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Literature Corpus work: 41d76060-c002-528a-9929-c98aa6f67ced
DOI: 10.1101/2021.12.22.473302

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