Article
Partial reprogramming restores youthful gene expression through transient suppression of cell identity
2021-05-23
Abstract excerpt
Transient induction of pluripotent reprogramming factors has been reported to reverse some features of aging in mammalian cells and tissues. However, the impact of transient reprogramming on somatic cell identity programs and the necessity of individual pluripotency factors remain unknown. Here, we mapped trajectories of transient reprogramming in young and aged cells from multiple murine cell types using single c...
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Identifiers and source
- Literature Corpus work
- d6258bc7-3683-5141-abf6-be9134221e3d
- DOI
- 10.1101/2021.05.21.444556