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Molecular Insights into Reprogramming-Initiation Events Mediated by the OSKM Gene Regulatory Network

31 Aug 2011

Abstract excerpt

Somatic cells can be reprogrammed to induced pluripotent stem cells by over-expression of OCT4, SOX2, KLF4 and c-MYC (OSKM). With the aim of unveiling the early mechanisms underlying the induction of pluripotency, we have analyzed transcriptional profiles at 24, 48 and 72 hours post-transduction of OSKM into human foreskin fibroblasts. Experiments confirmed that upon viral transduction, the immediate response is...

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PMID: 21909390
DOI: 10.1371/journal.pone.0024351

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