Article

In vivo reprogramming leads to premature death due to hepatic and intestinal failure

2022-05-27

Abstract excerpt

<h4>SUMMARY</h4> The induction of cellular reprogramming by forced expression of the transcription factors OCT4, SOX2, KLF4, and C-MYC (OSKM) has been shown to allow the dedifferentiation of somatic cells and ameliorate age-associated phenotypes in multiple tissues and organs. Yet to date, the benefits of in vivo reprogramming are limited by the occurrence of detrimental side-effects. Here, using complementary ge...

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Literature Corpus work: 8d9eb2de-a8ea-53fc-86c1-97321850a10e
DOI: 10.1101/2022.05.27.493700

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