Article

Non-viral induction of transient cell reprogramming in skeletal muscle to enhance tissue regeneration

2017-01-18

Abstract excerpt

Somatic cells can be reprogrammed to pluripotency in vivo by overexpression of defined transcription factors. While their sustained expression triggers tumorigenesis, transient reprogramming induces pluripotency-like features and proliferation only temporarily, without teratoma formation. We sought to achieve transient reprogramming within mouse skeletal muscle with a localized injection of plasmid DNA (pDNA) and...

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Literature Corpus work: 5c9d77a1-a630-5086-8525-16374786cb1f
DOI: 10.1101/101188

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