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Article

The Differential Effect of Apyrase Treatment and hCD39 Overexpression on Chronic Renal Fibrosis After Ischemia-Reperfusion Injury.

Transplantation - 1 Jul 2017

Roberts Veena, Campbell Duncan J, Lu Bo, Chia Joanne, Cowan Peter J, Dwyer Karen M

Abstract excerpt

BACKGROUND: Renal ischemia-reperfusion injury (IRI) leads to acute kidney injury and renal fibrosis. CD39 is a key purinergic enzyme in the hydrolysis of adenosine triphosphate (ATP) and increased CD39 enzymatic activity protects from acute IRI but its effect on renal fibrosis is not known. METHODS: Using a mouse model of unilateral renal IRI, the effects of increased CD39 activity (using soluble apyrase and mice...

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Source

Identifiers

PMID: 28198766
DOI: 10.1097/TP.0000000000001679

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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