Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice.

Arteriosclerosis, thrombosis, and vascular biology - 1 Sept 2016

Covarrubias Roman, Chepurko Elena, Reynolds Adam, Huttinger Zachary M, Huttinger Ryan, Stanfill Katherine, Wheeler Debra G, Novitskaya Tatiana, Robson Simon C, Dwyer Karen M, Cowan Peter J, Gumina Richard J

Abstract excerpt

OBJECTIVE: Circulating blood cells and endothelial cells express ectonucleoside triphosphate diphosphohydrolase-1 (CD39) and ecto-5'-nucleotidase (CD73). CD39 hydrolyzes extracellular ATP or ADP to AMP. CD73 hydrolyzes AMP to adenosine. The goal of this study was to examine the interplay between CD39 and CD73 cascade in arterial thrombosis. APPROACH AND RESULTS: To determine how CD73 activity influences in vivo...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to 5'-Nucleotidase
Share to Adenosine

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Adenosine Diphosphate

Share to Adenosine Monophosphate

Share to Apyrase

Share to Arterial Occlusive Diseases

Share to Ferric Compounds

Share to Platelet Activation

Source

Open in PubMed Open full text

Identifiers

PMID: 27417582
DOI: 10.1161/ATVBAHA.116.307374
PMCID: PMC5206760

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice.PMID 27417582Read ↗

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.Semantic proximity Read ↗

Endothelial-targeted CD39 prevents Toxin-induced Pulmonary Hypertension MiceSemantic proximity Read ↗

Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.Semantic proximity Read ↗

Purinergic dysregulation in pulmonary hypertension.Semantic proximity Read ↗

CD39 polymorphism enables lung thrombosis in sickle cell disease.Semantic proximity Read ↗

Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Lack of canonical PAR4 activation is associated with reduced arterial and venous thrombosis in miceSemantic proximity Read ↗

Role of p38 mitogen-activated protein kinase in thrombus formation.Semantic proximity Read ↗

Jak2 V617F clonal hematopoiesis promotes arterial thrombosis via platelet activation and cross talkSemantic proximity Read ↗

Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Disordered cellular migration and angiogenesis in cd39-null mice.Semantic proximity Read ↗

Protection against thrombosis in mice lacking PAR3.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.