Article

Endothelial-targeted CD39 prevents Toxin-induced Pulmonary Hypertension Mice

2025-11-07

Abstract excerpt

Disruption of the pulmonary endothelium by drugs, toxins, viruses (e.g., COVID-19), or bacterial sepsis can cause acute pulmonary vasculopathy leading to pulmonary hypertension and consequential heart failure. CD39 is a membrane-anchored ecto-enzyme expressed on endothelial cells (EC), integral in maintaining the antithrombotic profile of the endothelium. This ecto-enzyme works in concert with CD73 to hydrolyze bo...

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Literature Corpus work: e6981f57-c823-5306-9004-3319b4cb8b00
DOI: 10.1101/2025.11.05.686887

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