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Article

Renal Fibrosis Is Significantly Attenuated Following Targeted Disruption of Cd40 in Experimental Renal Ischemia.

Journal of the American Heart Association - 7 Apr 2020

Zhang Shungang, Breidenbach Joshua D, Khalaf Fatimah K, Dube Prabhatchandra R, Mohammed Chrysan J, Lad Apurva, Stepkowski Stanislaw, Hinds Terry D, Kumarasamy Sivarajan, Kleinhenz Andrew, Tian Jiang, Malhotra Deepak, Kennedy David J, Cooper Christopher J, Haller Steven T

Abstract excerpt

Background Renal artery stenosis is a common cause of renal ischemia, contributing to the development of chronic kidney disease. To investigate the role of local CD40 expression in renal artery stenosis, Goldblatt 2-kidney 1-clip surgery was performed on hypertensive Dahl salt-sensitive rats (S rats) and genetically modified S rats in which CD40 function is abolished (Cd40mutant). Methods and Results Four weeks...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 32200719
DOI: 10.1161/JAHA.119.014072
PMCID: PMC7428653

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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