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Article

Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.

Journal of lipid research - 1 Jul 2017

De Giorgi Marco, Enjyoji Keiichi, Jiang Gordon, Csizmadia Eva, Mitsuhashi Shuji, Gumina Richard J, Smolenski Ryszard T, Robson Simon C

Abstract excerpt

Cd39 scavenges extracellular ATP and ADP, ultimately generating adenosine, a nucleoside, which has anti-inflammatory effects in the vasculature. We have evaluated the role of Cd39 in the development of atherosclerosis in hyperlipidemic mice. ApoE KO (Cd39+/+/ApoE-/-) and Cd39/ApoE double KO (DKO) (Cd39-/-/ApoE-/-) mice were maintained on chow or Western diet for up to 20 weeks before evaluation of atherosclerotic...

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Identifiers

PMID: 28487312
DOI: 10.1194/jlr.M072132
PMCID: PMC5496028

Genes

ABCA1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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