Article
Regulation of renin release via cyclic ADP-ribose-mediated signaling: evidence from mice lacking CD38 gene.
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology - 1 Jan 2013
Xiong Jing, Xia Min, Yi Fan, Abais Justine M, Li Ningjun, Boini Krishna M, Li Pin-Lan
Abstract excerpt
BACKGROUND/AIMS: Despite extensive studies, the intracellular regulatory mechanism of renin production and release is still poorly understood. The present study was designed to test whether CD38-ADP-ribosylcyclase signaling pathway contributes to the regulation of renin production and release, and to examine whether CD38 gene knockout (CD38(-/-)) can change this important renal endocrinal function. METHODS:...
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