Article
Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.
PloS one - 1 Jan 2012
Blume Cornelia, Felix Agnieszka, Shushakova Nelli, Gueler Faikah, Falk Christine Susanne, Haller Hermann, Schrader Juergen
Abstract excerpt
Extracellular adenosine formed by 5'-ectonucleotidase (CD73) is involved in tubulo-glomerular feedback in the kidney but is also known to be an important immune modulator. Since CD73(-/-)mutant mice exhibit a vascular proinflammatory phenotype, we asked whether long term lack of CD73 causes inflammation related kidney pathologies. CD73(-/-)mice (13 weeks old) showed significantly increased low molecule...
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