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Article

Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.

PloS one - 1 Jan 2012

Blume Cornelia, Felix Agnieszka, Shushakova Nelli, Gueler Faikah, Falk Christine Susanne, Haller Hermann, Schrader Juergen

Abstract excerpt

Extracellular adenosine formed by 5'-ectonucleotidase (CD73) is involved in tubulo-glomerular feedback in the kidney but is also known to be an important immune modulator. Since CD73(-/-)mutant mice exhibit a vascular proinflammatory phenotype, we asked whether long term lack of CD73 causes inflammation related kidney pathologies. CD73(-/-)mice (13 weeks old) showed significantly increased low molecule...

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Identifiers

PMID: 22666342
DOI: 10.1371/journal.pone.0037100
PMCID: PMC3362584

Genes

MIP
TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Autoimmunity in CD73/Ecto-5'-nucleotidase deficient mice induces renal injury.PMID 22666342Read ↗

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