Article

CD73-derived adenosine at the blood-brain barrier confers protection in a mouse model of ischemic stroke

2026-06-24

Abstract excerpt

<h4>ABSTRACT</h4> Ischemic stroke remains a leading cause of death and disability, and current reperfusion therapies do not address the secondary neuroinflammatory response following blood–brain barrier (BBB) disruption. Purinergic signaling critically regulates this process: extracellular ATP promotes inflammation, whereas its enzymatic conversion into adenosine exerts tissue-protective effects. Notably, the ect...

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Literature Corpus work: f25b3fbe-541d-576e-9b78-a3f37d2b95c3
DOI: 10.64898/2026.06.19.732935

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