Article
Chronic renal failure in a mouse model of human adenine phosphoribosyltransferase deficiency.
The American journal of physiology - 1 Jul 1998
Stockelman M G, Lorenz J N, Smith F N, Boivin G P, Sahota A, Tischfield J A, Stambrook P J
Abstract excerpt
In humans, adenine phosphoribosyltransferase (APRT, EC 2.4.2.7) deficiency can manifest as nephrolithiasis, interstitial nephritis, and chronic renal failure. APRT catalyzes synthesis of AMP from adenine and 5-phosphoribosyl-1-pyrophosphate. In the absence of APRT, 2,8-dihydroxyadenine (DHA) is p...
Topics
- Adenine Phosphoribosyltransferase
- Aging
- Allopurinol
- Animals
- Chimera
- Creatinine
- Disease Models, Animal
- Female
- Genotype
- Glomerular Filtration Rate
- Humans
- Kidney
- Kidney Calculi
- Kidney Cortex
- Kidney Failure, Chronic
- Male
- Mice
- Mice, Inbred Strains