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Article

A3 adenosine receptor knockout mice are protected against ischemia- and myoglobinuria-induced renal failure.

American journal of physiology. Renal physiology - 1 Feb 2003

Lee H Thomas, Ota-Setlik Ayuko, Xu Hua, D'Agati Vivette D, Jacobson Marlene A, Emala Charles W

Abstract excerpt

A(3) adenosine receptor (AR) activation and inhibition worsen and improve, respectively, renal function after ischemia-reperfusion (I/R) injury in rats. We sought to further characterize the role of A(3) ARs in modulating renal function after either I/R or myoglobinuric renal injury. A(3) knockout mice had significantly lower plasma creatinines compared with C57 controls 24 h after I/R or myoglobinuric renal...

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Identifiers

PMID: 12388399
DOI: 10.1152/ajprenal.00271.2002

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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