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Article

A1 adenosine receptor knockout mice exhibit increased renal injury following ischemia and reperfusion.

American journal of physiology. Renal physiology - 1 Feb 2004

Lee H Thomas, Xu Hua, Nasr Samih H, Schnermann Jurgen, Emala Charles W

Abstract excerpt

Controversy exists regarding the effect of A1 adenosine receptor (AR) activation in the kidney during ischemia and reperfusion (I/R) injury. We sought to further characterize the role of A1 ARs in modulating renal function after I/R renal injury using both pharmacological and gene deletion approaches in mice. A1 AR knockout mice (A1KO) or their wild-type littermate controls (A1WT) were subjected to 30 min of...

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Identifiers

PMID: 14600029
DOI: 10.1152/ajprenal.00185.2003

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TNF

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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