Article
Purinergic dysregulation in pulmonary hypertension.
American journal of physiology. Heart and circulatory physiology - 1 Jul 2016
Visovatti Scott H, Hyman Matthew C, Goonewardena Sascha N, Anyanwu Anuli C, Kanthi Yogendra, Robichaud Patrick, Wang Jintao, Petrovic-Djergovic Danica, Rattan Rahul, Burant Charles F, Pinsky David J
Abstract excerpt
Despite the fact that nucleotides and adenosine help regulate vascular tone through purinergic signaling pathways, little is known regarding their contributions to the pathobiology of pulmonary arterial hypertension, a condition characterized by elevated pulmonary vascular resistance and remodeling. Even less is known about the potential role that alterations in CD39 (ENTPD1), the ectonucleotidase responsible for...
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