Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.

The Journal of clinical investigation - 1 May 2004

Dwyer Karen M, Robson Simon C, Nandurkar Harshal H, Campbell Duncan J, Gock Hilton, Murray-Segal Lisa J, Fisicaro Nella, Mysore Tharun B, Kaczmarek Elzbieta, Cowan Peter J, d'Apice Anthony J F

Abstract excerpt

Extracellular nucleotides play an important role in thrombosis and inflammation, triggering a range of effects such as platelet activation and recruitment, endothelial cell activation, and vasoconstriction. CD39, the major vascular nucleoside triphosphate diphosphohydrolase (NTPDase), converts ATP and ADP to AMP, which is further degraded to the antithrombotic and anti-inflammatory mediator adenosine. Deletion of...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine
Share to Adenosine Monophosphate

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Apyrase

Share to Blood Platelets

Share to Bone Marrow Transplantation

Share to Mice, Inbred CBA

Share to Thrombosis

Share to Transplantation Immunology

Source

Open in PubMed Open full text

Identifiers

PMID: 15146241
DOI: 10.1172/JCI19560
PMCID: PMC406523

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Thromboregulatory manifestations in human CD39 transgenic mice and the implications for thrombotic disease and transplantation.PMID 15146241Read ↗

Role of the CD39/CD73 Purinergic Pathway in Modulating Arterial Thrombosis in Mice.Semantic proximity Read ↗

Endothelial-targeted CD39 prevents Toxin-induced Pulmonary Hypertension MiceSemantic proximity Read ↗

Purinergic dysregulation in pulmonary hypertension.Semantic proximity Read ↗

CD39 polymorphism enables lung thrombosis in sickle cell disease.Semantic proximity Read ↗

Endothelial Effects of Simultaneous Expression of Human HO-1, E5NT, and ENTPD1 in a MouseSemantic proximity Read ↗

A HUMAN CD46 TRANSGENIC PIG MODEL SYSTEM FOR THE STUDY OF DISCORDANT XENOTRANSPLANTATIONSemantic proximity Read ↗

Complete deletion of Cd39 is atheroprotective in apolipoprotein E-deficient mice.Semantic proximity Read ↗

Thymidine phosphorylase participates in platelet signaling and promotes thrombosis.Semantic proximity Read ↗

Endothelial -targeted CD39 is protective in a mouse model of global forebrain ischaemiaSemantic proximity Read ↗

Disordered cellular migration and angiogenesis in cd39-null mice.Semantic proximity Read ↗

Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway.Semantic proximity Read ↗

Intravascular thrombosis in discordant xenotransplantation.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.