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Article

Dynamic assembly of Hda and the sliding clamp in the regulation of replication licensing.

Nucleic acids research - 20 Apr 2017

Kim Jin S, Nanfara Michael T, Chodavarapu Sundari, Jin Kyeong S, Babu Vignesh M P, Ghazy Mohamed A, Chung Scisung, Kaguni Jon M, Sutton Mark D, Cho Yunje

Abstract excerpt

Regulatory inactivation of DnaA (RIDA) is one of the major regulatory mechanisms of prokaryotic replication licensing. In RIDA, the Hda-sliding clamp complex loaded onto DNA directly interacts with adenosine triphosphate (ATP)-bound DnaA and stimulates the hydrolysis of ATP to inactivate DnaA. A prediction is that the activity of Hda is tightly controlled to ensure that replication initiation occurs only once per...

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Identifiers

PMID: 28168278
DOI: 10.1093/nar/gkx081
PMCID: PMC5397184

Genes

RIDA

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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