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Article

An isolated Hda-clamp complex is functional in the regulatory inactivation of DnaA and DNA replication.

Journal of structural biology - 1 Oct 2006

Kawakami Hironori, Su'etsugu Masayuki, Katayama Tsutomu

Abstract excerpt

In Escherichia coli, a complex consisting of Hda and the DNA-loaded clamp-subunit of the DNA polymerase III holoenzyme promotes hydrolysis of DnaA-ATP. The resultant ADP-DnaA is inactive for initiation of chromosomal DNA replication, thereby repressing excessive initiations. As the cellular content of the clamp is 10-100 times higher than that of Hda, most Hda molecules might be complexed with the clamp in vivo....

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Identifiers

PMID: 16603382
DOI: 10.1016/j.jsb.2006.02.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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