Article
ATPase switches controlling DNA replication initiation.
Current opinion in cell biology - 1 Jun 2000
Lee D G, Bell S P
Abstract excerpt
Proteins that bind and hydrolyze ATP are frequently involved in the early steps of DNA replication. Recent studies of Saccharomyces cerevisiae suggest that two members of the AAA+ ATPase family--the origin recognition complex and Cdc6p--have separable roles for ATP binding and ATP hydrolysis during eukaryotic DNA replication. Intriguingly, the proposed regulation of these eukaryotic replication proteins by ATP...
Topics
- Adenosine Triphosphatases
- Adenosine Triphosphate
- Bacterial Proteins
- Cell Cycle Proteins
- DNA Helicases
- DNA Replication
- DNA-Binding Proteins
- Escherichia coli
- Escherichia coli Proteins
- Fungal Proteins
- Mutation