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Article

Regulatory dynamics in the ternary DnaA complex for initiation of chromosomal replication in Escherichia coli.

Nucleic acids research - 1 Dec 2017

Sakiyama Yukari, Kasho Kazutoshi, Noguchi Yasunori, Kawakami Hironori, Katayama Tsutomu

Abstract excerpt

In Escherichia coli, the level of the ATP-DnaA initiator is increased temporarily at the time of replication initiation. The replication origin, oriC, contains a duplex-unwinding element (DUE) flanking a DnaA-oligomerization region (DOR), which includes twelve DnaA-binding sites (DnaA boxes) and the DNA-bending protein IHF-binding site (IBS). Although complexes of IHF and ATP-DnaA assembly on the DOR unwind the...

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Identifiers

PMID: 29040689
DOI: 10.1093/nar/gkx914
PMCID: PMC5716108

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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