Article

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanism

2020-02-18

Abstract excerpt

<h4>SUMMARY</h4> DNA replication requires the sliding clamp, a ring-shaped protein complex that encircles DNA, where it acts as an essential cofactor for DNA polymerases and other proteins. The sliding clamp needs to be actively opened and installed onto DNA by a clamp loader ATPase of the AAA+ family. The human clamp loader Replication Factor C (RFC) and sliding clamp PCNA are both essential and play critical ro...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: e24fe087-2d6e-5898-89d0-ef10565a2a96
DOI: 10.1101/2020.02.18.953257

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Structure of the human clamp loader bound to the sliding clamp: a further twist on AAA+ mechanismDOI 10.1101/2020.02.18.953257Read

Cryo-EM reveals a nearly complete PCNA loading process and unique features of the human alternative clamp loader CTF18-RFCSemantic proximity Read

Structural basis of human PCNA sliding on DNA.Semantic proximity Read

A central swivel point in the RFC clamp loader controls PCNA opening and loading on DNA.Semantic proximity Read

Structure of the human RNA Polymerase I Elongation ComplexSemantic proximity Read

Faf1 accelerates p97-mediated protein unfolding by promoting ubiquitin engagementSemantic proximity Read

Mechanism of proliferating cell nuclear antigen clamp opening by replication factor C.Semantic proximity Read

Structure of human RNA Polymerase IIISemantic proximity Read

Cryo-EM structure of the human CST•Polα/Primase complex in a recruitment stateSemantic proximity Read

The structure of a ring-opened proliferating cell nuclear antigen-replication factor C complex revealed by fluorescence energy transfer.Semantic proximity Read

Reconstitution of human DNA licensing and the structural and functional analysis of key intermediatesSemantic proximity Read

DNA clamp function of the mono-ubiquitinated Fanconi Anemia FANCI-FANCD2 complexSemantic proximity Read

Mechanistic insights into chromatin modulation by the “orphan” remodeler ATRXSemantic proximity Read