Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein.

Journal of bacteriology - 1 May 2003

Camara Johanna Eltz, Skarstad Kirsten, Crooke Elliott

Abstract excerpt

Regulatory inactivation of DnaA helps ensure that the Escherichia coli chromosome is replicated only once per cell cycle, through accelerated hydrolysis of active replication initiator ATP-DnaA to inactive ADP-DnaA. Analysis of deltahda strains revealed that the regulatory inactivation of DnaA component Hda is necessary for maintaining controlled initiation but not for cell growth or viability.

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphatases
Share to Cell Division
Share to Chromosomes, Bacterial

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to DNA, Bacterial

Share to DNA Replication

Share to Escherichia coli Proteins

Share to Flow Cytometry

Share to Transduction, Genetic

Source

Open in PubMed Open full text

Identifiers

PMID: 12730188
DOI: 10.1128/JB.185.10.3244-3248.2003
PMCID: PMC154069

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Controlled initiation of chromosomal replication in Escherichia coli requires functional Hda protein.PMID 12730188Read ↗

Hda inactivation of DnaA is the predominant mechanism preventing hyperinitiation of Escherichia coli DNA replication.Semantic proximity Read ↗

Modes of overinitiation, dnaA gene expression, and inhibition of cell division in a novel cold-sensitive hda mutant of Escherichia coli.Semantic proximity Read ↗

HdaB: a novel and conserved DnaA-related protein that targets the RIDA process to stimulate replication initiation.Semantic proximity Read ↗

Suppressors of DnaA(ATP) imposed overinitiation in Escherichia coli.Semantic proximity Read ↗

Countermeasures to survive excessive chromosome replication in Escherichia coli.Semantic proximity Read ↗

A novel regulatory mechanism couples deoxyribonucleotide synthesis and DNA replication in Escherichia coli.Semantic proximity Read ↗

Insufficient levels of the nrdAB-encoded ribonucleotide reductase underlie the severe growth defect of the Δhda E. coli strain.Semantic proximity Read ↗

A nucleotide switch in the Escherichia coli DnaA protein initiates chromosomal replication: evidnece from a mutant DnaA protein defective in regulatory ATP hydrolysis in vitro and in vivo.Semantic proximity Read ↗

A role for nonessential domain II of initiator protein, DnaA, in replication control.Semantic proximity Read ↗

Negative control of replication initiation by a novel chromosomal locus exhibiting exceptional affinity for Escherichia coli DnaA protein.Semantic proximity Read ↗

Research on DnaA in the early days.Semantic proximity Read ↗

The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.