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Article

The interaction of DiaA and DnaA regulates the replication cycle in E. coli by directly promoting ATP DnaA-specific initiation complexes.

Genes & development - 15 Aug 2007

Keyamura Kenji, Fujikawa Norie, Ishida Takuma, Ozaki Shogo, Su'etsugu Masayuki, Fujimitsu Kazuyuki, Kagawa Wataru, Yokoyama Shigeyuki, Kurumizaka Hitoshi, Katayama Tsutomu

Abstract excerpt

Escherichia coli DiaA is a DnaA-binding protein that is required for the timely initiation of chromosomal replication during the cell cycle. In this study, we determined the crystal structure of DiaA at 1.8 A resolution. DiaA forms a homotetramer consisting of a symmetrical pair of homodimers. Mutational analysis revealed that the DnaA-binding activity and formation of homotetramers are required for the...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Identifiers

PMID: 17699754
DOI: 10.1101/gad.1561207
PMCID: PMC1948862

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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