HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.

doi:10.1016/j.ajhg.2016.09.023

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Community

Back to search

Article

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.

American journal of human genetics - 1 Dec 2016

Vince Nicolas, Li Hongchuan, Ramsuran Veron, Naranbhai Vivek, Duh Fuh-Mei, Fairfax Benjamin P, Saleh Bahara, Knight Julian C, Anderson Stephen K, Carrington Mary

Abstract excerpt

Differential HLA-C levels influence several human diseases, but the mechanisms responsible are incompletely characterized. Using a validated prediction algorithm, we imputed HLA-C cell surface levels in 228 individuals from the 1000 Genomes dataset. We tested 68,726 SNPs within the MHC for association with HLA-C level. The HLA-C promoter region variant, rs2395471, 800 bp upstream of the transcription start site,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Algorithms

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Datasets as Topic

Share to Genome, Human

Share to HeLa Cells

Share to HLA-C Antigens

Share to Octamer Transcription Factor-1

Share to Quantitative Trait Loci

Share to Transcription Initiation Site

Source

Open in PubMed Open full text

Identifiers

PMID: 27817866
DOI: 10.1016/j.ajhg.2016.09.023
PMCID: PMC5142108

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.PMID 27817866Read ↗

A statistical genetics guide to identifying HLA alleles driving complex diseaseSemantic proximity Read ↗

Structural and regulatory diversity shape HLA-C protein expression levels.Semantic proximity Read ↗

Imputing HLA-G high-resolution alleles and regulatory haplotypes from exomes and SNP array data.Semantic proximity Read ↗

HLA-F transcriptional and protein differential expression according to its genetic polymorphisms.Semantic proximity Read ↗

Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease.Semantic proximity Read ↗

Fine-mapping SLE-MHC associations revealed independent contributions of HLA missense variants and<i>C4</i>copy number variationsSemantic proximity Read ↗

Insights into HLA-G Genetics Provided by Worldwide Haplotype DiversitySemantic proximity Read ↗

Immunogenetics of HLA-B: SNP, allele, and haplotype diversity in populations from different continents and ancestry backgrounds.Semantic proximity Read ↗

HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus.Semantic proximity Read ↗

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.Semantic proximity Read ↗

The influence of HLA genetic variation on plasma protein expressionSemantic proximity Read ↗

In-depth genetic analysis of 6p21.3 reveals insights into associations between HLA types and complex traits and diseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.