Article

The influence of HLA genetic variation on plasma protein expression

2023-07-26

Abstract excerpt

Polymorphism in the human leukocyte antigen class I (HLA-I) and class II (HLA-II) genes is strongly implicated in susceptibility to immune-mediated diseases. However, the molecular effects of HLA genetic variation, including and beyond antigen presentation, remain unclear. Here we examined the effect of HLA genetic variation on the expression of 2940 plasma proteins using imputed HLA variants in 45,330 Europeans i...

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Literature Corpus work: 5b8e81c8-7739-5be2-bd4c-cd8a2c6ec6d2
DOI: 10.1101/2023.07.24.550394

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