Article

A statistical genetics guide to identifying HLA alleles driving complex disease

2022-08-26

Abstract excerpt

The human leukocyte antigen (HLA) locus is associated with more human complex diseases than any other locus. In many diseases it explains more heritability than all other known loci combined. Investigators have now demonstrated the accuracy of in silico HLA imputation methods. These approaches enable rapid and accurate estimation of HLA alleles in the millions of individuals that are already genotyped on microarr...

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Literature Corpus work: ba3232ab-d2d2-528a-9b1b-69cec4bc65ed
DOI: 10.1101/2022.08.24.504550

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