Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Structural and regulatory diversity shape HLA-C protein expression levels.

Nature communications - 26 Jun 2017

Kaur Gurman, Gras Stephanie, Mobbs Jesse I, Vivian Julian P, Cortes Adrian, Barber Thomas, Kuttikkatte Subita Balaram, Jensen Lise Torp, Attfield Kathrine E, Dendrou Calliope A, Carrington Mary, McVean Gil, Purcell Anthony W, Rossjohn Jamie, Fugger Lars

Abstract excerpt

Expression of HLA-C varies widely across individuals in an allele-specific manner. This variation in expression can influence efficacy of the immune response, as shown for infectious and autoimmune diseases. MicroRNA binding partially influences differential HLA-C expression, but the additional contributing factors have remained undetermined. Here we use functional and structural analyses to demonstrate that...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Exons
Share to Gene Expression Regulation

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to HLA-C Antigens

Share to Mammals

Share to Pan troglodytes

Share to Peptides

Share to Promoter Regions, Genetic

Share to Protein Binding

Source

Open in PubMed Open full text

Identifiers

PMID: 28649982
DOI: 10.1038/ncomms15924
PMCID: PMC5490200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Structural and regulatory diversity shape HLA-C protein expression levels.PMID 28649982Read ↗

Differential microRNA regulation of HLA-C expression and its association with HIV control.Semantic proximity Read ↗

HLA-C Level Is Regulated by a Polymorphic Oct1 Binding Site in the HLA-C Promoter Region.Semantic proximity Read ↗

Hla-C genetic diversity and evolutionary insights in two samples from Brazil and Benin.Semantic proximity Read ↗

Distinguishing functional polymorphism from random variation in the sequences of >10,000 HLA-A, -B and -C alleles.Semantic proximity Read ↗

Influence of HLA-C expression level on HIV control.Semantic proximity Read ↗

HLA-G genetic diversity and evolutive aspects in worldwide populations.Semantic proximity Read ↗

Factors affecting HLA expression: A reviewSemantic proximity Read ↗

HLA Genes: A Hallmark of Functional Genetic Variation and Complex Evolution.Semantic proximity Read ↗

Structural variation shapes regulatory and evolutionary diversity at the HLA locusSemantic proximity Read ↗

Immunogenetics of HLA-B: SNP, allele, and haplotype diversity in populations from different continents and ancestry backgrounds.Semantic proximity Read ↗

Molecular characterization of the archaic HLA-B∗73:01 allele reveals presentation of a unique peptidome and skewed engagement by KIR2DL2.Semantic proximity Read ↗

Identification of an elaborate NK-specific system regulating HLA-C expression.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.