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Fine-mapping SLE-MHC associations revealed independent contributions of HLA missense variants and<i>C4</i>copy number variations

2024-11-23

Abstract excerpt

Systemic lupus erythematosus (SLE) is a complex autoimmune disease with strong genetic associations within the major histocompatibility complex (MHC) region. Despite significant advances, precisely pinpointing the genetic variants that contribute to SLE risk within the MHC remains challenging. This study aimed to comprehensively profile SLE-driving variants using a newly developed East Asian MHC imputation referen...

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Literature Corpus work
aa81a831-1824-5c4b-8685-fbb9e793a3ec
DOI
10.1101/2024.11.21.24317596
Open publication

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Fine-mapping SLE-MHC associations revealed independent contributions of HLA missense variants and<i>C4</i>copy number variationsDOI 10.1101/2024.11.21.24317596
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