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Imputing HLA-G high-resolution alleles and regulatory haplotypes from exomes and SNP array data.

Human immunology - 1 Apr 2026

Barbosa Rafaela Miranda, Brito Silva Nayane Dos Santos, Meyer Diogo, Bourguiba-Hachemi Sonia, Donadi Eduardo A, Vince Nicolas, Castelli Erick C

Abstract excerpt

HLA-G encodes an immune checkpoint molecule with restricted expression in immune-privileged tissues and pathological conditions. It exhibits limited coding diversity but substantial regulatory-region variation influencing expression levels. Strong linkage disequilibrium across HLA-G creates a structured genetic architecture in which regulatory and coding variants co-segregate into well-defined haplotypes,...

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PMID: 41724095
DOI: 10.1016/j.humimm.2026.111700

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