Article
Tutorial: a statistical genetics guide to identifying HLA alleles driving complex disease.
Nature protocols - 1 Sept 2023
Sakaue Saori, Gurajala Saisriram, Curtis Michelle, Luo Yang, Choi Wanson, Ishigaki Kazuyoshi, Kang Joyce B, Rumker Laurie, Deutsch Aaron J, Schönherr Sebastian, Forer Lukas, LeFaive Jonathon, Fuchsberger Christian, Han Buhm, Lenz Tobias L, de Bakker Paul I W, Okada Yukinori, Smith Albert V, Raychaudhuri Soumya
Abstract excerpt
The human leukocyte antigen (HLA) locus is associated with more complex diseases than any other locus in the human genome. In many diseases, HLA explains more heritability than all other known loci combined. In silico HLA imputation methods enable rapid and accurate estimation of HLA alleles in the millions of individuals that are already genotyped on microarrays. HLA imputation has been used to define causal...
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