Article
Immunogenetics of HLA-B: SNP, allele, and haplotype diversity in populations from different continents and ancestry backgrounds.
HLA - 1 Jun 2023
Silva Nayane Dos Santos Brito, Souza Andreia da Silva, Andrade Heloisa de Souza, Pereira Raphaela Neto, Castro Camila Ferreira Bannwart, Vince Nicolas, Limou Sophie, Naslavsky Michel Satya, Zatz Mayana, Duarte Yeda Aparecida de Oliveira, Mendes-Junior Celso Teixeira, Castelli Erick da Cruz
Abstract excerpt
HLA-B is among the most variable gene in the human genome. This gene encodes a key molecule for antigen presentation to CD8+ T lymphocytes and NK cell modulation. Despite the myriad of studies evaluating its coding region (with an emphasis on exons 2 and 3), few studies evaluated introns and regulatory sequences in real population samples. Thus, HLA-B variability is probably underestimated. We applied a...
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