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Article

Phenome-wide scanning identifies multiple diseases and disease severity phenotypes associated with HLA variants.

Science translational medicine - 10 May 2017

Karnes Jason H, Bastarache Lisa, Shaffer Christian M, Gaudieri Silvana, Xu Yaomin, Glazer Andrew M, Mosley Jonathan D, Zhao Shilin, Raychaudhuri Soumya, Mallal Simon, Ye Zhan, Mayer John G, Brilliant Murray H, Hebbring Scott J, Roden Dan M, Phillips Elizabeth J, Denny Joshua C

Abstract excerpt

Although many phenotypes have been associated with variants in human leukocyte antigen (HLA) genes, the full phenotypic impact of HLA variants across all diseases is unknown. We imputed HLA genomic variation from two populations of 28,839 and 8431 European ancestry individuals and tested association of HLA variation with 1368 phenotypes. A total of 104 four-digit and 92 two-digit HLA allele phenotype associations...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Genome-Wide Association Study

Share to Histocompatibility Antigens Class II

Share to HLA-DQ beta-Chains

Share to Polymorphism, Single Nucleotide

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Identifiers

PMID: 28490672
DOI: 10.1126/scitranslmed.aai8708
PMCID: PMC5563969

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