Article
HLA-G variability and haplotypes detected by massively parallel sequencing procedures in the geographicaly distinct population samples of Brazil and Cyprus.
Molecular immunology - 1 Mar 2017
Castelli Erick C, Gerasimou Petroula, Paz Michelle A, Ramalho Jaqueline, Porto Iane O P, Lima Thálitta H A, Souza Andréia S, Veiga-Castelli Luciana C, Collares Cristhianna V A, Donadi Eduardo A, Mendes-Junior Celso T, Costeas Paul
Abstract excerpt
The HLA-G molecule presents immunomodulatory properties that might inhibit immune responses when interacting with specific Natural Killer and T cell receptors, such as KIR2DL4, ILT2 and ILT4. Thus, HLA-G might influence the outcome of situations in which fine immune system modulation is required, such as autoimmune diseases, transplants, cancer and pregnancy. The majority of the studies regarding the HLA-G gene...
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