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Article

Single Nucleotide Polymorphisms in Cellular Drug Transporters Are Associated with Intolerance to Antiretroviral Therapy in Brazilian HIV-1 Positive Individuals.

PloS one - 1 Jan 2016

Arruda Mônica Barcellos, Campagnari Francine, de Almeida Tailah Bernardo, Couto-Fernandez José Carlos, Tanuri Amilcar, Cardoso Cynthia Chester

Abstract excerpt

Adverse reactions are the main cause of treatment discontinuation among HIV+ individuals. Genes related to drug absorption, distribution, metabolism and excretion (ADME) influence drug bioavailability and treatment response. We have investigated the association between single nucleotide polymorphisms (SNPs) in 29 ADME genes and intolerance to therapy in a case-control study including 764 individuals. Results...

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Source

Open in PubMed Open full text

Identifiers

PMID: 27648838
DOI: 10.1371/journal.pone.0163170
PMCID: PMC5029869

Genes

ABCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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