Article
The dual role of pharmacogenetics in HIV treatment: mutations and polymorphisms regulating antiretroviral drug resistance and disposition.
Pharmacological reviews - 1 Jul 2012
Michaud Veronique, Bar-Magen Tamara, Turgeon Jacques, Flockhart David, Desta Zeruesenay, Wainberg Mark A
Abstract excerpt
Significant intra- and interindividual variability has been observed in response to use of pharmacological agents in treatment of HIV infection. Treatment of HIV infection is limited by high rates of adverse drug reactions and development of resistance in a significant proportion of patients as a result of suboptimal drug concentrations. The efficacy of antiretroviral therapy is challenged by the emergence of...
Topics
Join the communities discussing this publication.