Article
ABCB1 and ABCC1 variants associated with virological failure of first-line protease inhibitors antiretroviral regimens in Northeast Brazil patients.
Journal of clinical pharmacology - 1 Dec 2013
Coelho Antonio V C, Silva Suedja P S, de Alencar Luiz C A, Stocco Gabriele, Crovella Sergio, Brandão Lucas A C, Guimarães Rafael L
Abstract excerpt
The present study aims at evaluating the association between seven single nucleotide polymorphisms (SNPs) in five genes involved on antiretroviral pharmacokinetic pathways and virological failure in first line highly active antiretroviral therapy. Seven candidate polymorphisms (rs3842 and rs1045642 in ABCB1, rs212091 and rs3743527 in ABCC1, rs3745274 in CYP2B6, in SLC22A1 and in SLCO3A1) were...