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Article

Differences in genetic variants in lopinavir disposition among HIV-infected Bantu Africans.

Pharmacogenomics - 1 May 2016

Mpeta Bafokeng, Kampira Elizabeth, Castel Sandra, Mpye Keleabetswe L, Soko Nyarai D, Wiesner Lubbe, Smith Peter, Skelton Michelle, Lacerda Miguel, Dandara Collet

Abstract excerpt

INTRODUCTION: Variability in lopinavir (LPV) plasma concentration among patients could be due to genetic polymorphisms. This study set to evaluate significance of variants in CYP3A4/5, SLCO1B1 and ABCC2 on LPV plasma concentration among African HIV-positive patients. MATERIALS & METHODS: Eighty-six HIV-positive participants on ritonavir (LPV/r) were genetically characterized and LPV plasma concentration...

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Source

Identifiers

PMID: 27142945
DOI: 10.2217/pgs.16.14

Genes

ABCC2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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