Article
Polymorphisms at CYP enzymes, NR1I2 and NR1I3 in association with virologic response to antiretroviral therapy in Brazilian HIV-positive individuals.
The pharmacogenomics journal - 1 Feb 2022
de Almeida Velozo Camila, de Almeida Tailah Bernardo, de Azevedo Marcelo Costa Velho Mendes, Espasandin Isabela, da Cunha Pinto Jorge Francisco, López Sheila, Pizzatti Luciana, Tanuri Amilcar, da Silva Santos Sabrina, Ribeiro-Alves Marcelo, Cardoso Cynthia Chester
Abstract excerpt
Virologic failure of antiretroviral therapy (ART) may be explained by single nucleotide polymorphisms (SNPs) in drug absorption and metabolism genes. Here, we characterized the associations between polymorphisms in cytochrome P450 enzymes' genes CYP2B6 and CYP3A4/A5, nuclear receptor genes NR1I2/3, and initial ART efficacy among 203 HIV-positive individuals from Rio de Janeiro. Association between SNPs and...
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