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Variation in the plasma membrane monoamine transporter (PMAT, encoded in <i>SLC29A4</i> ) and organic cation transporter 1 (OCT1, encoded in <i>SLC22A1</i> ) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT study

2018-10-06

Abstract excerpt

<h4>Objectives</h4> 20-30% of patients with metformin treated type 2 diabetes experience gastrointestinal side effects leading to premature discontinuation in 5-10% of the cases. Gastrointestinal intolerance may reflect localised high concentrations of metformin in the gut. We hypothesized that reduced transport of metformin into the circulation via the plasma membrane monoamine transporter (PMAT) and organic cat...

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Literature Corpus work
bd170d65-57d1-5020-a5df-b811c2189196
DOI
10.1101/436980
Open publication

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Variation in the plasma membrane monoamine transporter (PMAT, encoded in <i>SLC29A4</i> ) and organic cation transporter 1 (OCT1, encoded in <i>SLC22A1</i> ) and gastrointestinal intolerance to metformin in type 2 diabetes: an IMI DIRECT studyDOI 10.1101/436980
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