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Article

Influence of SLCO1B1 polymorphisms on lopinavir Ctrough in Serbian HIV/AIDS patients.

British journal of clinical pharmacology - 1 Jul 2020

Dragović Gordana, Dimitrijević Božana, Kušić Jovana, Soldatović Ivan, Jevtović Djordje, Olagunju Adeniyi, Owen Andrew

Abstract excerpt

AIMS: Lopinavir (LPV) is not a first-line regimen. According to recent WHO data, LPV usage in low- and middle-income countries accounted for approximately 52% of the adult and 23% of the paediatric protease inhibitor market in 2017. Since LPV is a substrate for the SLCO1B1 (OATP1B1) transporter, the aim of this study was to assess the impact of SLCO1B1 polymorphisms (rs11045819, rs4149032 and rs4149056) on LPV...

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Share to Child
Share to Genotype
Share to HIV Infections
Share to HIV Protease Inhibitors
Share to Liver-Specific Organic Anion Transporter 1
Share to Lopinavir
Share to Polymorphism, Genetic
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Identifiers

PMID: 32022294
DOI: 10.1111/bcp.14230
PMCID: PMC7319006

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