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Article

Association of functional genetic variation in PP2A with prefrontal working memory processing.

Behavioural brain research - 1 Jan 2017

Rampino Antonio, Di Carlo Pasquale, Fazio Leonardo, Ursini Gianluca, Pergola Giulio, De Virgilio Caterina, Gadaleta Gemma, Giordano Giulia Maria, Bertolino Alessandro, Blasi Giuseppe

Abstract excerpt

Variation in prefrontal dopaminergic signaling mediated by D2 receptor has been implicated in cognitive phenotypes of schizophrenia, including working memory. Molecular cascades downstream of D2 receptor include a cAMP-dependent- and a cAMP-independent-pathway. Protein-Phosphatase-2A (PP2A) is a key partner of D2 receptor in cAMP-independent signaling. This enzyme comprises a regulatory subunit that is coded by...

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Identifiers

PMID: 27591184
DOI: 10.1016/j.bbr.2016.08.054

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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