Article
Genetic variation in the schizophrenia-risk gene neuregulin1 correlates with differences in frontal brain activation in a working memory task in healthy individuals.
NeuroImage - 1 Oct 2008
Krug Axel, Markov Valentin, Eggermann Thomas, Krach Sören, Zerres Klaus, Stöcker Tony, Shah N Jon, Schneider Frank, Nöthen Markus M, Treutlein Jens, Rietschel Marcella, Kircher Tilo
Abstract excerpt
Working memory dysfunctions are a prominent feature in schizophrenia. These impairments have been linked to alterations in prefrontal brain activation with studies reporting hypo- and hyperactivations. Since schizophrenia has a high heritability, it is of interest whether susceptibility genes modulate working memory and its neural correlates. The aim of the present study was to test the influence of the NRG1...
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