Cognitive Characterization of Schizophrenia Risk Variants Involved in Synaptic Transmission: Evidence of CACNA1C's Role in Working Memory.

doi:10.1038/npp.2017.123

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Article

Cognitive Characterization of Schizophrenia Risk Variants Involved in Synaptic Transmission: Evidence of CACNA1C's Role in Working Memory.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Dec 2017

Cosgrove Donna, Mothersill Omar, Kendall Kimberley, Konte Bettina, Harold Denise, Giegling Ina, Hartmann Annette, Richards Alex, Mantripragada Kiran, Owen Michael J, O'Donovan Michael C, Gill Michael, Rujescu Dan, Walters James, Corvin Aiden, Morris Derek W, Donohoe Gary

Abstract excerpt

With >100 common variants associated with schizophrenia risk, establishing their biological significance is a priority. We sought to establish cognitive effects of risk variants at loci implicated in synaptic transmission by (1) identifying GWAS schizophrenia variants whose associated gene function is related to synaptic transmission, and (2) testing for association between these and measures of neurocognitive...

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PMID: 28607492
DOI: 10.1038/npp.2017.123
PMCID: PMC5686488

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

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